In this paper, the effect of total solid content in slurry, inlet temperature and outlet temperature of spraying drier on the yield of cheese powder were analyzed by orthogonal rotational regression design. The regression equation was established and the spraying drier conditions were optimized. 针对影响干酪粉出品率的喷雾干燥条件,采用三因素二次通用旋转回归设计对其进行了优化,并建立了回归方程。